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TREX1 Polyclonal Antibody, FITC

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TREX1 Polyclonal Antibody, FITC

Product Details

TREX1-FITC

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 220-245 on human TREX1 protein.
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Trex1 (ATRIP) is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3' repair exonuclease 1; 3'-5' exonuclease TREX1; Deoxyribonuclease III; DNase III; three prime exonuclease 1; Three-prime repair exonuclease 1; TREX1; trophoblast expressed 1; unnamed protein product

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Gene Aliases: 1661; AGS1; AU041952; CRV; DRN3; HERNS; RGD1309596; RVCLS; TREX1

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UniProt ID: (Human) Q9NSU2, (Mouse) Q91XB0

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Entrez Gene ID: (Human) 11277, (Rat) 100049583, (Mouse) 22040

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Function(s)
magnesium ion binding nucleic acid binding DNA binding double-stranded DNA binding single-stranded DNA binding nuclease activity exonuclease activity exodeoxyribonuclease activity protein binding 3'-5'-exodeoxyribonuclease activity DNA binding, bending double-stranded DNA 3'-5' exodeoxyribonuclease activity 3'-5' exonuclease activity hydrolase activity MutLalpha complex binding MutSalpha complex binding adenyl deoxyribonucleotide binding identical protein binding protein homodimerization activity metal ion binding WW domain binding exodeoxyribonuclease III activity
Process(es)
DNA damage checkpoint blood vessel development kidney development adaptive immune response organ or tissue specific immune response activation of immune response macrophage activation involved in immune response lymphoid progenitor cell differentiation immune response in brain or nervous system inflammatory response to antigenic stimulus T cell antigen processing and presentation regulation of immunoglobulin production heart morphogenesis heart process atrial cardiac muscle tissue development generation of precursor metabolites and energy regulation of glycolytic process DNA metabolic process DNA replication DNA repair mismatch repair DNA modification DNA catabolic process DNA recombination inflammatory response immune response cellular response to DNA damage stimulus determination of adult lifespan response to UV regulation of gene expression regulation of fatty acid metabolic process regulation of metabolic process mitotic G1 DNA damage checkpoint transposition, RNA-mediated regulation of type I interferon production regulation of tumor necrosis factor production cellular response to oxidative stress cellular response to reactive oxygen species cellular response to UV cellular response to interferon-beta apoptotic cell clearance regulation of cellular respiration innate immune response regulation of innate immune response establishment of protein localization negative regulation of innate immune response regulation of lipid biosynthetic process regulation of inflammatory response protein stabilization regulation of T cell activation defense response to virus type I interferon signaling pathway negative regulation of type I interferon-mediated signaling pathway regulation of protein complex stability cellular response to type I interferon cellular response to gamma radiation cellular response to hydroxyurea immune complex formation cGAS/STING signaling pathway negative regulation of cGAS/STING signaling pathway DNA synthesis involved in UV-damage excision repair regulation of lysosome organization DNA catabolic process, exonucleolytic nucleic acid phosphodiester bond hydrolysis
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