This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
PA5-19426 targets TRF2 in IF and WB applications and shows reactivity with Human samples.
The PA5-19426 immunogen is synthetic peptide derived from residues 250 - 350 of Human TRF2.
PA5-19426 detects TRF2 which has a predicted molecular weight of approximately 65 kDa and 69 kDa.
Store antibody at 4°C for 1-2 weeks. For long-term storage, store at -20°C.
TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Telomeric DNA-binding protein; telomeric repeat binding protein 2; Telomeric repeat-binding factor 2; TRBF2, TRF2, TTAGGG repeat-binding factor 2; TTAGGG repeat-binding factor 2
Gene Aliases: TERF2; TRBF2; TRF2
UniProt ID: (Human) Q15554
Entrez Gene ID: (Human) 7014
Molecular Function: nucleic acid binding