Immunogen sequence: STGKEDKQPA PGPVEKPPRE PARQLRNPPT TIGMMTLKAA FKTLSGAQDS EAAFAKLDQK DLVLPTQALP ASPALKNKRP RKDENESSAP ADGEGGSELQ PKNKRMTISR LVLEEDSQST EPS
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
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Protein Aliases: Telomeric DNA-binding protein; telomeric repeat binding protein 2; Telomeric repeat-binding factor 2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
Gene Aliases: TERF2; TRBF2; TRF2
UniProt ID: (Human) Q15554
Entrez Gene ID: (Human) 7014
Molecular Function: nucleic acid binding