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Invitrogen
TRIB2 Polyclonal Antibody
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FIGURE: 1 / 1
TRIB2 Antibody (PA5-88200) in WB
Western blot analysis of TRIB2 in extracts of various cell lines. Samples were incubated with TRIB2 Polyclonal antibody (Product # PA5-88200) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-88200
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human TRIB2 (NP_0676751)
Conjugate
Form
Liquid
Concentration
3.89 mg/mL
Amount
389 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFDISCYQES LAPCFCLSAH SNINQITEII; Positive Samples: K-562, 293T, Raji, Mouse kidney; Cellular Location: Cytoplasm, cytoskeleton
Target Information
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ser/thr kinase; TRB-2; trib2; TRIB2 (HGNC:30809); Tribbles homolog 2; unnamed protein product
Gene Aliases: AW319517; C5FW; GS3955; TRB-2; TRB2; TRIB2
UniProt ID: (Human) Q92519, (Mouse) Q8K4K3
Entrez Gene ID: (Human) 28951, (Mouse) 217410
nucleotide binding
protein kinase activity
protein kinase inhibitor activity
protein binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
ATP binding
transcription factor binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of interleukin-10 production
regulation of MAP kinase activity
negative regulation of fat cell differentiation
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of interleukin-10 biosynthetic process
regulation of catalytic activity
positive regulation of ubiquitin-protein transferase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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