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Immunogen sequence: MDFSVKVDI EKEVTCPICL ELLTEPLSLD CGHSFCQACI TAKIKESVII SRGESSCPVC QTRFQPGNLR PNRHLANIVE RVKEVKMSPQ EGQKRDVCEH HGKKLQIFCK EDGKVICWVC ELSQEHQGHQ TFRINEVVKE CQEKLQVALQ RLIKEDQEAE KLEDDIRQER TAWKNYIQIE RQKILKGFNE MRVILDNEEQ RELQKLEEGE VNVLDNLAAA TDQLVQQRQD ASTLISDLQR RLRGSSVEML QDVIDVMKRS ESWTLKKPKS VSKKLKSVFR VPDLSGMLQV LKELTDVQYY WVDVMLNPGS ATSNVAISVD QRQVKTVRTC TFKNSNPCDF SAFGVFGCQY F (1-350 aa encoded by BC035582)
TRIM22 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.
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Protein Aliases: 50 kDa-stimulated trans-acting factor; E3 ubiquitin-protein ligase TRIM22; RING finger protein 94; RING-type E3 ubiquitin transferase TRIM22; Staf-50; stimulated trans-acting factor (50 kDa); tripartite binding motif 22; tripartite motif protein TRIM22; tripartite motif-containing 22; Tripartite motif-containing protein 22
Gene Aliases: GPSTAF50; RNF94; STAF50; TRIM22
UniProt ID: (Human) Q8IYM9
Entrez Gene ID: (Human) 10346
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