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Proteintech

TRIM24 Polyclonal Antibody

53 References
View all (35) TRIM24 antibodies
Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

14208-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 24 publications 24 publications

Immunohistochemistry (IHC)

-
View 15 publications 15 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:500
View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg
View 5 publications 5 publications

ChIP assay (ChIP)

Assay-dependent
View 4 publications 4 publications

Not applicable (N/A)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRIM24 Fusion Protein Ag5417 (701-1050 aa encoded by BC028689)
View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: SKPAGADST HKVPVVMLEP IRIKQENSGP PENYDFPVVI VKQESDEESR PQNANYPRSI LTSLLLNSSQ SSTSEETVLR SDAPDSTGDQ PGLHQDNSSN GKSEWLDPSQ KSPLHVGETR KEDDPNEDWC AVCQNGGELL CCEKCPKVFH LSCHVPTLTN FPSGEWICTF CRDLSKPEVE YDCDAPSHNS EKKKTEGLVK LTPIDKRKCE RLLLFLYCHE MSLAFQDPVP LTVPDYYKII KNPMDLSTIK KRLQEDYSMY SKPEDFVADF RLIFQNCAEF NEPDSEVANA GIKLENYFEE LLKNLYPEKR FPKPEFRNES EDNKFSDDSD DDFVQPRKKR LKSIEERQLL K (701-1050 aa encoded by BC028689)

Target Information

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Ab2-427; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; TIF1-alpha; Transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; transcriptional intermediary factor 1, alpha; tripartite motif-containing 24; Tripartite motif-containing protein 24

Gene Aliases: A130082H20Rik; AI447469; D430004I05Rik; hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1-alpha; TIF1A; TIF1ALPHA; TRIM24

UniProt ID: (Human) O15164, (Mouse) Q64127

Entrez Gene ID: (Human) 8805, (Rat) 500084, (Mouse) 21848

Molecular Function: chromatin/chromatin-binding, or -regulatory protein

Function(s)
transcription from RNA polymerase II promoter negative regulation of cell proliferation protein ubiquitination peptidyl-tyrosine phosphorylation protein catabolic process regulation of protein stability regulation of apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated protein autophosphorylation calcium ion homeostasis regulation of vitamin D receptor signaling pathway cellular response to estrogen stimulus regulation of signal transduction by p53 class mediator protein phosphorylation positive regulation of gene expression response to peptide hormone transcription, DNA-templated regulation of transcription, DNA-templated regulation of nucleic acid-templated transcription
Process(es)
p53 binding chromatin binding transcription coactivator activity protein tyrosine kinase activity ubiquitin-protein transferase activity receptor binding protein binding zinc ion binding ligase activity ligand-dependent nuclear receptor binding estrogen response element binding methylated histone binding sequence-specific DNA binding ubiquitin protein ligase activity lysine-acetylated histone binding molecular_function protein kinase activity DNA binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
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