PA5-30640 targets TRIM25 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30640 immunogen is recombinant protein fragment corresponding to a region within amino acids 243 and 491 of Human TRIM25.
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.
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Protein Aliases: E3 ubiquitin/ISG15 ligase TRIM25; EFP; Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; RING-type E3 ubiquitin transferase TRIM25; RNF147; tripartite motif protein TRIM25; tripartite motif-containing 25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Z147; zinc finger protein; Zinc finger protein 147; zinc finger protein 147 (estrogen-responsive finger protein); zinc finger protein-147; ZNF147
Gene Aliases: EFP; RNF147; TRIM25; Z147; ZNF147
UniProt ID: (Human) Q14258
Entrez Gene ID: (Human) 7706