PA5-27603 targets TRIM27 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-27603 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 218 of Human TRIM27.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.
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Protein Aliases: Ret finger protein; RFP transforming protein; RING finger protein 76; RING-type E3 ubiquitin transferase TRIM27; RNF76; tripartite motif protein 27; tripartite motif protein TRIM27; tripartite motif-containing 27; Tripartite motif-containing protein 27; Zinc finger protein RFP
Gene Aliases: AW538890; Gm19403; RFP; RNF76; TRIM27