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TRIM31 Polyclonal Antibody

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Antibody Testing Data (3)

TRIM31 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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TRIM31 Antibody (12543-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 12543-1-AP (TRIM31 antibody) at dilution of 1:50 (under 10x lens).

TRIM31 Antibody in Immunoprecipitation (IP)

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Product Details

12543-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRIM31 Fusion Protein Ag3264 (126-425 aa encoded by BC017017)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: HNVSLIEEA AQNYQGQIQE QIQVLQQKEK ETVQVKAQGV HRVDVFTDQV EHEKQRILTE FELLHQVLEE EKNFLLSRIY WLGHEGTEAG KHYVASTEPQ LNDLKKLVDS LKTKQNMPPR QLLEDIKVVL CRSEEFQFLN PTPVPLELEK KLSEAKSRHD SITGSLKKFK DQLQADRKKD ENRFFKSMNK NDMKSWGLLQ KNNHKMNKTS EPGSSSAGGR TTSGPPNHHS SAPSHSLFRA SSAGKVTFPV CLLASYDEIS GQGASSQDTK TFDVALSEEL HAALSEWLTA IRAWFCKVPS S (126-425 aa encoded by BC017017)

Target Information

TRIM31 encodes for a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells.

Odontology

Yi X,Song Y,Xu J,Wang L,Liu L,Huang D,Zhang L

Mon Jan 01 00:00:00 EST 2024

NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells.

Odontology

Yi X,Song Y,Xu J,Wang L,Liu L,Huang D,Zhang L

Mon Jan 01 00:00:00 EST 2024

Parthenolide alleviates microglia-mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder.

International immunopharmacology

Fan M,Wang C,Zhao X,Jiang Y,Wang C

Sat Jul 01 00:00:00 EDT 2023

The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.

Redox biology

Zeng S,Zhao Z,Zheng S,Wu M,Song X,Li Y,Zheng Y,Liu B,Chen L,Gao C,Liu H

Wed Sep 01 00:00:00 EDT 2021

The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.

Redox biology

Zeng S,Zhao Z,Zheng S,Wu M,Song X,Li Y,Zheng Y,Liu B,Chen L,Gao C,Liu H

Wed Sep 01 00:00:00 EDT 2021

The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.

Redox biology

Zeng S,Zhao Z,Zheng S,Wu M,Song X,Li Y,Zheng Y,Liu B,Chen L,Gao C,Liu H

Wed Sep 01 00:00:00 EDT 2021

The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.

Redox biology

Zeng S,Zhao Z,Zheng S,Wu M,Song X,Li Y,Zheng Y,Liu B,Chen L,Gao C,Liu H

Wed Sep 01 00:00:00 EDT 2021

Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.

Molecular cell

Zhu J,Li X,Cai X,Zha H,Zhou Z,Sun X,Rong F,Tang J,Zhu C,Liu X,Fan S,Wang J,Liao Q,Ouyang G,Xiao W

Thu Aug 05 00:00:00 EDT 2021

Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.

Molecular cell

Zhu J,Li X,Cai X,Zha H,Zhou Z,Sun X,Rong F,Tang J,Zhu C,Liu X,Fan S,Wang J,Liao Q,Ouyang G,Xiao W

Thu Aug 05 00:00:00 EDT 2021

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

Cell death & disease

Guo Y,Li Q,Zhao G,Zhang J,Yuan H,Feng T,Ou D,Gu R,Li S,Li K,Lin P

Thu Oct 14 00:00:00 EDT 2021

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

Cell death & disease

Guo Y,Li Q,Zhao G,Zhang J,Yuan H,Feng T,Ou D,Gu R,Li S,Li K,Lin P

Thu Oct 14 00:00:00 EDT 2021

USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.

Nature communications

Hou J,Han L,Zhao Z,Liu H,Zhang L,Ma C,Yi F,Liu B,Zheng Y,Gao C

Thu May 20 00:00:00 EDT 2021

Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.

Communications biology

Ning L,Ko JM,Yu VZ,Ng HY,Chan CK,Tao L,Lam SY,Leong MM,Ngan RK,Kwong DL,Lee AW,Ng WT,Cheng A,Tung S,Lee VH,Lam KO,Kwan CK,Li WS,Yau S,Bei JX,Lung ML

Fri Dec 11 00:00:00 EST 2020

Nasopharyngeal carcinoma MHC region deep sequencing identifies HLA and novel non-HLA TRIM31 and TRIM39 loci.

Communications biology

Ning L,Ko JM,Yu VZ,Ng HY,Chan CK,Tao L,Lam SY,Leong MM,Ngan RK,Kwong DL,Lee AW,Ng WT,Cheng A,Tung S,Lee VH,Lam KO,Kwan CK,Li WS,Yau S,Bei JX,Lung ML

Fri Dec 11 00:00:00 EST 2020

AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.

Journal of immunology (Baltimore, Md. : 1950)

Zhao W,Shi CS,Harrison K,Hwang IY,Nabar NR,Wang M,Kehrl JH

Thu Oct 15 00:00:00 EDT 2020

TRIM31 enhances chemoresistance in glioblastoma through activation of the PI3K/Akt signaling pathway.

Experimental and therapeutic medicine

Fan MD,Zhao XY,Qi JN,Jiang Y,Liu BY,Dun ZP,Zhang R,Wang CW,Pang Q

Sat Aug 01 00:00:00 EDT 2020

Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.

Experimental cell research

Guo P,Qiu Y,Ma X,Li T,Ma X,Zhu L,Lin Y,Han L

Sun Jul 01 00:00:00 EDT 2018

Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.

Experimental cell research

Guo P,Qiu Y,Ma X,Li T,Ma X,Zhu L,Lin Y,Han L

Sun Jul 01 00:00:00 EDT 2018

Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.

Experimental cell research

Guo P,Qiu Y,Ma X,Li T,Ma X,Zhu L,Lin Y,Han L

Sun Jul 01 00:00:00 EDT 2018

Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.

Experimental cell research

Guo P,Qiu Y,Ma X,Li T,Ma X,Zhu L,Lin Y,Han L

Sun Jul 01 00:00:00 EDT 2018

TRIM31 regulates chronic inflammation via NF-κB signal pathway to promote invasion and metastasis in colorectal cancer.

American journal of translational research

Wang H,Yao L,Gong Y,Zhang B

Fri Apr 08 00:00:00 EDT 2022

TRIM31 regulates chronic inflammation via NF-κB signal pathway to promote invasion and metastasis in colorectal cancer.

American journal of translational research

Wang H,Yao L,Gong Y,Zhang B

Fri Apr 08 00:00:00 EDT 2022

TRIM31 regulates chronic inflammation via NF-κB signal pathway to promote invasion and metastasis in colorectal cancer.

American journal of translational research

Wang H,Yao L,Gong Y,Zhang B

Fri Apr 08 00:00:00 EDT 2022

TRIM31 regulates chronic inflammation via NF-κB signal pathway to promote invasion and metastasis in colorectal cancer.

American journal of translational research

Wang H,Yao L,Gong Y,Zhang B

Fri Apr 08 00:00:00 EDT 2022

TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells.

Nature communications

Ra EA,Lee TA,Won Kim S,Park A,Choi HJ,Jang I,Kang S,Hee Cheon J,Cho JW,Eun Lee J,Lee S,Park B

Tue May 24 00:00:00 EDT 2016

TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells.

Nature communications

Ra EA,Lee TA,Won Kim S,Park A,Choi HJ,Jang I,Kang S,Hee Cheon J,Cho JW,Eun Lee J,Lee S,Park B

Tue May 24 00:00:00 EDT 2016

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.

Journal of virology

Uchil PD,Hinz A,Siegel S,Coenen-Stass A,Pertel T,Luban J,Mothes W

Tue Jan 01 00:00:00 EST 2013

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.

Journal of virology

Uchil PD,Hinz A,Siegel S,Coenen-Stass A,Pertel T,Luban J,Mothes W

Tue Jan 01 00:00:00 EST 2013

Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase TRIM31; tripartite motif-containing 31; Tripartite motif-containing protein 31

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Gene Aliases: C6orf13; HCG1; HCGI; RNF; TRIM31

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UniProt ID: (Human) Q9BZY9

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Entrez Gene ID: (Human) 11074

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Function(s)

protein binding zinc ion binding ligase activity ubiquitin-protein ligase

Process(es)

protein ubiquitination negative regulation of viral transcription innate immune response negative regulation of viral entry into host cell positive regulation of sequence-specific DNA binding transcription factor activity interferon-gamma-mediated signaling pathway regulation of viral release from host cell

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TRIM31 Polyclonal Antibody

TRIM31 Antibody (12543-1-AP) in IHC (P)

Product Details

12543-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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