TRIM32 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM32 localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes.
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Protein Aliases: 72 kDa Tat interacting protein; 72 kDa Tat-interacting protein; BBS11; bM468K2.2 (tripartite motif protein 32); E3 ubiquitin-protein ligase TRIM32; HT2A; LGMD2H; RING-type E3 ubiquitin transferase TRIM32; TAT-interactive protein, 72-KD; TATIP; TRIM32; tripartite motif containing 32; tripartite motif protein 32; tripartite motif-containing 32; Tripartite motif-containing protein 32; zinc finger protein 117; Zinc finger protein HT2A; zinc-finger protein HT2A
Gene Aliases: 1810045E12Rik; 3f3; BBS11; HT2A; LGMD2H; TATIP; TRIM32; Zfp117