Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
FIGURE: 1 / 1
Positive test controls include: HeLa, SGC-7901, Mouse stomach. The target is usually found in the following locations: Cytoplasm, Nucleus, P-body.
Immunogen sequence: EKLLLFCQED GKVICWLCER SQEHRGHHTF LTEEVAREYQ VKLQAALEML RQKQQEAEEL EADIREEKAS WKTQIQYDKT NVLADFEQLR DILDWEESNE L
The protein encoded by this gene is a member of the tripartite motif family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coiled-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiquitinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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Protein Aliases: RING finger protein 88; RING-type E3 ubiquitin transferase TRIM5; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant kappa; tripartite motif protein TRIM5; Tripartite motif-containing protein 5
Gene Aliases: EG667823; Gm8833; RGD1304579; RNF88; TRIM5; TRIM5alpha
UniProt ID: (Human) Q9C035
Entrez Gene ID: (Human) 85363, (Mouse) 667823, (Rat) 308906
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