This antibody is specific to TRIM63.
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase TRIM63; FLJ32380; Iris RING finger protein; MURF 1; MURF-1; muscle ring finger protein 1; muscle specific ring finger protein 2; Muscle-specific RING finger protein 1; OTTHUMP00000008701; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; RNF 28; Striated muscle RING zinc finger protein; TRIM 63; tripartite motif containing 63, E3 ubiquitin protein ligase; tripartite motif protein 63; tripartite motif-containing 63; Tripartite motif-containing protein 63
Gene Aliases: IRF; Murf; MURF1; MURF2; RF1; RNF28; SMRZ; TRIM63
Molecular Function: ubiquitin-protein ligase