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Proteintech
TRIM63 Polyclonal Antibody
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Product Details
55456-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Amount
100.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to TRIM63.
Target Information
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase TRIM63; FLJ32380; Iris RING finger protein; MURF 1; MURF-1; muscle ring finger protein 1; muscle specific ring finger protein 2; Muscle-specific RING finger protein 1; OTTHUMP00000008701; RING finger protein 28; RING-type E3 ubiquitin transferase TRIM63; RNF 28; Striated muscle RING zinc finger protein; TRIM 63; tripartite motif containing 63, E3 ubiquitin protein ligase; tripartite motif protein 63; tripartite motif-containing 63; Tripartite motif-containing protein 63; unnamed protein product
Gene Aliases: IRF; Murf; MURF1; MURF2; RF1; RNF28; SMRZ; TRIM63
UniProt ID: (Human) Q969Q1, (Rat) Q91Z63
Entrez Gene ID: (Human) 84676, (Rat) 140939, (Mouse) 433766
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
titin binding
metal ion binding
ubiquitin protein ligase activity
ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
muscle contraction
signal transduction
negative regulation of cardiac muscle hypertrophy
skeletal muscle atrophy
response to electrical stimulus involved in regulation of muscle adaptation
protein ubiquitination
innate immune response
negative regulation of glycolytic process
response to glucocorticoid
response to interleukin-1
regulation of gene expression
response to denervation involved in regulation of muscle adaptation
proteasome-mediated ubiquitin-dependent protein catabolic process
cellular response to dexamethasone stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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