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|Tested species reactivity||Mouse|
|Published species reactivity||Not Applicable|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (NKLESTISAVQ ) corresponding to the internal amino acids of TRIM71|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
This antibody is predicted to react with bovine, canine, human and rat based on sequence homology.
TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development , and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Dual analysis of the murine cytomegalovirus and host cell transcriptomes reveal new aspects of the virus-host cell interface.
PA5-19282 was used in western blot to determine the roles of murine cytomegalovirus and host cell transcriptomes show new aspects of the virus-host cell interface
|Juranic Lisnic V,Babic Cac M,Lisnic B,Trsan T,Mefferd A,Das Mukhopadhyay C,Cook CH,Jonjic S,Trgovcich J||PLoS pathogens (9:null)||2013|
abnormal cell LINeage LIN-41; E3 ubiquitin-protein ligase TRIM71; homolog of C. elegans Lin-41; LIN-41; lin-41 homolog; LIN41; mLin41; Protein lin-41 homolog; TRIM71; tripartite motif-containing 71; Tripartite motif-containing protein 71
2610206G21Rik; AL022943; Gm1127; lin-41; Lin41; mlin-41; mLin41; Trim71