Search
Proteintech
TRIM72 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
22151-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRIM72 Fusion Protein Ag17756 (145-477 aa encoded by BC033211)
Conjugate
Form
Liquid
Concentration
0.77 mg/mL
Amount
115.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MRKEKSVAV LEHQLVEVEE TVRQFRGAVG EQLGKMRVFL AALEGSLDRE AERVRGEAGV ALRRELGSLN SYLEQLRQME KVLEEVADKP QTEFLMKYCL VTSRLQKILA ESPPPARLDI QLPIIS (145-477 aa encoded by BC033211)
Target Information
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Mg53; mitsugumin 53; Mitsugumin-53; trim72; trim72 {ECO:0000250|UniProtKB:Q8N4X6}; tripartite motif containing 72, E3 ubiquitin protein ligase; Tripartite motif-containing protein 72; unnamed protein product
Gene Aliases: BC067209; MG53; RGD1562778; TRIM72
UniProt ID: (Human) Q6ZMU5, (Mouse) Q1XH17, (Rat) A0JPQ4
Entrez Gene ID: (Human) 493829, (Mouse) 434246, (Rat) 365377
plasma membrane repair
muscle system process
exocytosis
muscle organ development
negative regulation of myotube differentiation
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of insulin-like growth factor receptor signaling pathway
innate immune response
negative regulation of insulin receptor signaling pathway
protein homooligomerization
transport
membrane budding
protein ubiquitination
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support