|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 82 and 258 of Human TRIM72|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-31233 targets TRIM72 in WB applications and shows reactivity with Human samples.
The PA5-31233 immunogen is recombinant protein fragment corresponding to a region within amino acids 82 and 258 of Human TRIM72.
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MG53; mitsugumin 53; Mitsugumin-53; TRIM72; tripartite motif containing 72, E3 ubiquitin protein ligase; tripartite motif-containing 72; Tripartite motif-containing protein 72
Gene Aliases: MG53; TRIM72
UniProt ID: (Human) Q6ZMU5
Entrez Gene ID: (Human) 493829
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