Suggested positive control: antigen standard for COPS2 (transient overexpression lysate).
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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Protein Aliases: Alien homolog; Alien protein; alien-like; alien-PA; alien-PB; alien-PD; alien-PE; CG9556-PA; CG9556-PB; CG9556-PD; CG9556-PE; COP9; COP9 (constitutive photomorphogenic) homolog, subunit 2; COP9 complex homolog subunit 2; COP9 constitutive photomorphogenic homolog subunit 2; COP9 signalosome complex subunit 2; d-Alien; Dch2; drosophila COP9 signalosome homolog 2; JAB1-containing signalosome subunit 2; SD08021p; SGN2; signalosome subunit 2; thyroid receptor interacting protein 15; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15; tyroid receptor interacting protein 15
Gene Aliases: AI315723; ALIEN; BcDNA:LD10463; C85265; CG9556; CH2; COPS2; CSN2; DCH2; Dmel\CG9556; Dmel_CG9556; SGN2; TRIP-15; TRIP15