This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
In direct ELISAs, approximately 30% cross-reactivity with recombinant human TROP-2 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 40kD glycoprotein, identified by monoclonal antibody GA733; Cell surface glycoprotein Trop-2; cell surface glycoprotein TROP2; epithelial glycoprotein-1; GA733; gastrointestinal tumor-associated antigen GA7331; lymphocyte antigen 97; Membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; Pancreatic carcinoma marker protein GA733-1; pancreatic carcinoma marker protein GA7331; Parturition-related protein 1; TACD2; truncated TACSTD2; Tumor-associated calcium signal transducer 2; tunor-associated calcium signal transducer 2
Gene Aliases: C80403; EGP-1; EGP1; GA733-1; GA7331; GP50; Ly97; M1S1; Prp1; TACSTD2; TROP2
Molecular Function: receptor