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Invitrogen
TRPC3 Polyclonal Antibody
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Product Details
PA5-20258
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide from near the carboxy terminus of human TRPC3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human brain tissue lysate.
PA5-20258 can be used with blocking peptide PEP-0394.
Target Information
The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hTrp-3; hTrp3; ion channel; mTrp3; Receptor-activated cation channel TRP3; Short transient receptor potential channel 3; Transient receptor protein 3; TRP-3; Trp-related protein 3; TrpC3
Gene Aliases: Mwk; SCA41; Trcp3; TRP3; TRPC3; Trrp3
UniProt ID: (Human) Q13507, (Mouse) Q9QZC1
Entrez Gene ID: (Human) 7222, (Mouse) 22065
ion transport
calcium ion transport
single fertilization
phototransduction
positive regulation of calcium ion transport into cytosol
response to ATP
ion transmembrane transport
regulation of cytosolic calcium ion concentration
response to calcium ion
transmembrane transport
calcium ion transmembrane transport
positive regulation of cardiac muscle hypertrophy in response to stress
transport
manganese ion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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