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Proteintech
TRPC5 Polyclonal Antibody
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Product Details
25890-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRPC5 Fusion Protein Ag23171 (756-973 aa encoded by BC137271)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EVLDLLGNR KHPRSFSTSS TELSQRDDNN DGSGGARAKS KSVSFNLGCK KKTCHGPPLI RTMPRSSGAQ GKSKAESSSK RSFMGPSLKK LGLLFSKFNG HMSEPSSEPM YTISDGIVQQ HCMWQDIRYS QMEKGKAEAC SQSEINLSEV ELGEVQGAAQ SSECPLACSS SLHCASSICS SNSKLLDSSE DVFETWGEAC DLLMHKWGDG QEEQVTTRL (756-973 aa encoded by BC137271)
Target Information
TRPC5 belongs to the transient receptor family. TRPC5 is one of the seven mammalian TRPC (transient receptor potential channel) proteins. The TRPC5 protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. TRPC5 also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). TRPC5 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC5 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, or G-protein coupled receptors. TRPC5 has also been shown to be calcium-selective, and may also be activated by intracellular calcium store depletion. Diseases associated with TRPC5 include Hypertrophic Pyloric Stenosis and Pyloric Stenosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Capacitative calcium entry channel 2; CCE2; Htrp-5; hTRP5; mtrp5; protein phosphatase 1, regulatory subunit 159; Short transient receptor potential channel 5; transient receptor potential channel 5; Transient receptor protein 5; TRP-5; Trp-related protein 5; TrpC5; vtransient receptor potential cation channel, subfamily C, member 5
Gene Aliases: CCE2; PPP1R159; TRP-5; TRP5; TRPC5; Trrp5
UniProt ID: (Human) Q9UL62, (Mouse) Q9QX29
Entrez Gene ID: (Human) 7224, (Mouse) 22067
ion transport
calcium ion transport
positive regulation of cytosolic calcium ion concentration
nervous system development
positive regulation of cell proliferation
neuron differentiation
ion transmembrane transport
positive regulation of neuron differentiation
positive regulation of axon extension
negative regulation of dendrite morphogenesis
neuron apoptotic process
regulation of cytosolic calcium ion concentration
transmembrane transport
calcium ion transmembrane transport
phosphatidylserine exposure on apoptotic cell surface
regulation of membrane hyperpolarization
transport
manganese ion transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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