Search
Bioss
TRPM2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
BS-2888R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TRPM2, amino acids 951-1050.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: calcium-permeable cation channel; N-terminal isoform; EC 3.6.1.13; EREG 1; EREG1; Estrogen-responsive element-associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; Transient receptor potential melastatin 2; transient receptor potential melastatin family 2; transient receptor protein 7; TRPC 7; TrpC7; TRPM 2; unnamed protein product
Gene Aliases: 9830168K16Rik; C79133; EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; Trp7; TRPC7; TRPM2; Trpm2-predicted; Trrp7
UniProt ID: (Human) O94759, (Rat) E9PTA2, (Mouse) Q91YD4
Entrez Gene ID: (Human) 7226, (Rat) 294329, (Mouse) 28240
ion channel activity
cation channel activity
calcium channel activity
sodium channel activity
manganese ion transmembrane transporter activity
calcium ion binding
calcium-release channel activity
hydrolase activity
metal ion binding
metal ion transmembrane transporter activity
ADP-ribose diphosphatase activity
mono-ADP-D-ribose binding
ligand-gated calcium channel activity
ion channel
transporter
temperature homeostasis
dendritic cell chemotaxis
ion transport
sodium ion transport
calcium ion transport
manganese ion transport
response to heat
response to purine-containing compound
calcium-mediated signaling
regulation of actin cytoskeleton organization
response to hydroperoxide
ion transmembrane transport
sodium ion transmembrane transport
release of sequestered calcium ion into cytosol
protein homotetramerization
regulation of filopodium assembly
transmembrane transport
cellular response to hydrogen peroxide
calcium ion transmembrane transport
cellular response to calcium ion
manganese ion transmembrane transport
cellular response to temperature stimulus
zinc II ion transmembrane transport
dendritic cell differentiation
calcium ion transmembrane import into cytosol
calcium ion import across plasma membrane
metabolic process
transport
cation transport
response to oxidative stress
positive regulation of insulin secretion
positive regulation of oxidative stress-induced neuron death
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support