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TRPM2 Polyclonal Antibody
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Product Details
OSR00131W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the 4th cytoplasmic domain of human TRPM2 (TRPC7, LTRPC2) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TRPM2.
Target Information
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium-permeable cation channel; N-terminal isoform; EC 3.6.1.13; EREG 1; EREG1; Estrogen-responsive element-associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; Transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; Transient receptor potential melastatin 2; TRPC 7; TrpC7; TRPM 2; unnamed protein product
Gene Aliases: EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; TRPC7; TRPM2
UniProt ID: (Human) O94759
Entrez Gene ID: (Human) 7226
ion channel activity
cation channel activity
calcium channel activity
sodium channel activity
manganese ion transmembrane transporter activity
calcium ion binding
calcium-release channel activity
hydrolase activity
metal ion binding
metal ion transmembrane transporter activity
ADP-ribose diphosphatase activity
mono-ADP-D-ribose binding
ligand-gated calcium channel activity
temperature homeostasis
dendritic cell chemotaxis
ion transport
sodium ion transport
calcium ion transport
manganese ion transport
response to heat
response to purine-containing compound
calcium-mediated signaling
regulation of actin cytoskeleton organization
response to hydroperoxide
ion transmembrane transport
sodium ion transmembrane transport
release of sequestered calcium ion into cytosol
protein homotetramerization
regulation of filopodium assembly
transmembrane transport
cellular response to hydrogen peroxide
calcium ion transmembrane transport
cellular response to calcium ion
manganese ion transmembrane transport
cellular response to temperature stimulus
zinc II ion transmembrane transport
dendritic cell differentiation
calcium ion transmembrane import into cytosol
calcium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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