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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:3,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A synthesized peptide derived from human TRPM2, corresponding to a region within C-terminal amino acids. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 50% glycerol, 150mM NaCl |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2852233 |
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 3.6.1.13; EREG 1; Estrogen-responsive element-associated gene 1 protein; KNP 3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; transient receptor potential cation channel, subfamily M, member 2; Transient receptor potential channel 7; Transient receptor potential melastatin 2; transient receptor potential melastatin family 2; transient receptor protein 7; TRPC 7; TrpC7; TRPM 2
Gene Aliases: 9830168K16Rik; C79133; EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; Trp7; TRPC7; TRPM2; Trpm2-predicted; Trrp7
UniProt ID: (Human) O94759, (Rat) E9PTA2, (Mouse) Q91YD4
Entrez Gene ID: (Human) 7226, (Rat) 294329, (Mouse) 28240
Molecular Function:
ion channel
transporter
hydrolase
metabolite interconversion enzyme
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