Invitrogen

TRPM2 Polyclonal Antibody

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TRPM2 Antibody in Western Blot (WB) — Western blot analysis of TRPM2 in K562 cell lysate. Samples were incubated with TRPM2 polyclonal antibody (Product # PA5-102844).

TRPM2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of paraffin-embedded TRPM2 in human brain cancer tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with TRPM2 polyclonal antibody (Product # PA5-102844) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1000-1:3000

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TRPM2, corresponding to a region within C-terminal amino acids.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 150mM NaCl

Contains

0.02% sodium azide

Storage conditions

-20°C

RRID

AB_2852233

Target Information

TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: EC 3.6.1.13; EREG 1; Estrogen-responsive element-associated gene 1 protein; KNP 3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; transient receptor potential cation channel, subfamily M, member 2; Transient receptor potential channel 7; Transient receptor potential melastatin 2; transient receptor potential melastatin family 2; transient receptor protein 7; TRPC 7; TrpC7; TRPM 2

Gene Aliases: 9830168K16Rik; C79133; EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; Trp7; TRPC7; TRPM2; Trpm2-predicted; Trrp7

UniProt ID: (Human) O94759, (Rat) E9PTA2, (Mouse) Q91YD4

Entrez Gene ID: (Human) 7226, (Rat) 294329, (Mouse) 28240

Molecular Function: ion channel receptor transporter