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TRPM2 Antibody (PA5-22218) in IHC (P)
TRPM2 Polyclonal Antibody detects TRPM2 protein at cytoplasm in rat liver by immunohistochemical analysis. Sample: Paraffin-embedded rat liver. TRPM2 Polyclonal Antibody (Product # PA5-22218) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-22218
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 181 and 423 of TRPM2 (Uniprot ID#O94759)
Conjugate
Unconjugated
Form
Liquid
Concentration
1.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_11152374
Product Specific Information
Recommended positive controls: HepG2, HepG2 membrane extract.
Predicted reactivity: Mouse (90%), Rat (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 3.6.1.13; EREG 1; Estrogen-responsive element-associated gene 1 protein; KNP 3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; transient receptor potential cation channel, subfamily M, member 2; Transient receptor potential channel 7; Transient receptor potential melastatin 2; transient receptor potential melastatin family 2; TRPC 7; TrpC7; TRPM 2
Gene Aliases: EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; TRPC7; TRPM2; Trpm2-predicted
UniProt ID: (Human) O94759, (Rat) E9PTA2
Entrez Gene ID: (Human) 7226, (Rat) 294329
Molecular Function:
ion channel
transporter
hydrolase
metabolite interconversion enzyme
calcium ion transport
response to oxidative stress
positive regulation of insulin secretion
sodium ion transmembrane transport
estrous cycle
calcium ion transmembrane transport
calcium ion import across plasma membrane
positive regulation of oxidative stress-induced neuron death
manganese ion transport
metabolic process
response to hydroperoxide
manganese ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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