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Invitrogen
TRPM2 Polyclonal Antibody
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FIGURE: 1 / 4
TRPM2 Antibody (PA5-22218) in IHC (P)
TRPM2 Polyclonal Antibody detects TRPM2 protein at cytoplasm in rat liver by immunohistochemical analysis. Sample: Paraffin-embedded rat liver. TRPM2 Polyclonal Antibody (Product # PA5-22218) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-22218
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Intracellular domain of human TRPM2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.38 mg/mL
Amount
138 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HepG2, HepG2 membrane extract.
Predicted reactivity: Mouse (90%), Rat (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium-permeable cation channel; N-terminal isoform; EC 3.6.1.13; EREG 1; EREG1; Estrogen-responsive element-associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; Transient receptor potential melastatin 2; transient receptor potential melastatin family 2; TRPC 7; TrpC7; TRPM 2; unnamed protein product
Gene Aliases: EREG1; KNP3; LTrpC-2; LTRPC2; NUDT9H; NUDT9L1; TRPC7; TRPM2; Trpm2-predicted
UniProt ID: (Human) O94759, (Rat) E9PTA2
Entrez Gene ID: (Human) 7226, (Rat) 294329
ion channel activity
cation channel activity
calcium channel activity
sodium channel activity
manganese ion transmembrane transporter activity
calcium ion binding
calcium-release channel activity
hydrolase activity
metal ion binding
metal ion transmembrane transporter activity
ADP-ribose diphosphatase activity
mono-ADP-D-ribose binding
ligand-gated calcium channel activity
ion channel
transporter
temperature homeostasis
dendritic cell chemotaxis
ion transport
sodium ion transport
calcium ion transport
manganese ion transport
response to heat
response to purine-containing compound
calcium-mediated signaling
regulation of actin cytoskeleton organization
response to hydroperoxide
ion transmembrane transport
sodium ion transmembrane transport
release of sequestered calcium ion into cytosol
protein homotetramerization
regulation of filopodium assembly
transmembrane transport
cellular response to hydrogen peroxide
calcium ion transmembrane transport
cellular response to calcium ion
manganese ion transmembrane transport
cellular response to temperature stimulus
zinc II ion transmembrane transport
dendritic cell differentiation
calcium ion transmembrane import into cytosol
calcium ion import across plasma membrane
metabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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