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Product Details
PA5-22878
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide made to a C-terminal portion of the rat protein (within residues 1430-1508).
Conjugate
Excitation/Emission Max
492/519 nm
View spectra
Form
Liquid
Concentration
1.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
50mM sodium borate
Contains
no preservative
Storage conditions
4° C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155601
Target Information
TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.6.1.13; EREG 1; KNP 3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; transient receptor potential melastatin family 2; transient receptor protein 7; TRPC 7; TrpC7; TRPM 2
Gene Aliases: 9830168K16Rik; C79133; LTRPC2; Trp7; TRPC7; Trpm2; Trpm2-predicted; Trrp7
UniProt ID: (Rat) E9PTA2, (Mouse) Q91YD4
Entrez Gene ID: (Rat) 294329, (Mouse) 28240
manganese ion transport
metabolic process
response to hydroperoxide
manganese ion transmembrane transport
transport
ion transport
cation transport
sodium ion transport
calcium ion transport
response to oxidative stress
positive regulation of insulin secretion
ion transmembrane transport
transmembrane transport
calcium ion transmembrane transport
calcium ion import across plasma membrane
positive regulation of oxidative stress-induced neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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