Peptide sequence: EKHISEQRAG YGGTGSIEIP VLCLLVNGDP NTLERISRAV EQAAPWLILV
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 100%; Rat: 86%
This gene encodes a member of the transient receptor potential protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Caions. It is activated by lower concentrations of intracellular Ca, and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele.
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Protein Aliases: Long transient receptor potential channel 5; long transient receptor potential-related channel 5; LTrpC-5; LTRPC5; MLSN1 and TRP-related; MLSN1- and TRP-related gene 1 protein; MTR1; subfamily M member 5; Transient receptor potential cation channel; Transient receptor potential cation channel subfamily M member 5; transient receptor potential cation channel, subfamily M, member 5; TRPM5
Gene Aliases: 9430099A16Rik; LTrpC-5; LTRPC5; MTR1; TRPM5