|Tested species reactivity||Human|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic from the 4th cytoplasmic loop of human TRPM6|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:300-1:2000|
Reconstitute with 100 ul of distilled water.
Centrifuge to remove any insoluble material.
Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells). Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in H510 small cell lung carcinoma cells.
CHAK2; channel kinase 2; H; HMGX; HOMG; HSH; melastatin-related TRP cation channel 6; transient receptor potential cation channel, subfamily M, member 6
CHAK2; HMGX; HOMG; HOMG1; HSH; TRPM6