Immunogen sequence: SQPSCKSHLE TGTKDQETVC SKATEGDNTE FGAFVGHRDS MDLQRFKETS NKIKILSNNN TSENTLKRVS SLAGFTDCHR TSIPVHSKQA EKISRRPSTE DTHEVDSKAA LIPDWLQDRP SNREMPSEEG TLNGLTSPFK PAM
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.
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Protein Aliases: Channel kinase 1; Channel-kinase 1; FLJ20117; Long transient receptor potential channel 7; LTRPC ion channel family member 7; LTrpC-7; tr; Transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel, subfamily M, member 7; transient receptor potential-phospholipase C-interacting kinase; TRMP7; TRP PLIK
Gene Aliases: ALSPDC; CHAK; CHAK1; LTrpC-7; LTRPC7; TRP-PLIK; TRPM7
UniProt ID: (Human) Q96QT4
Entrez Gene ID: (Human) 54822