TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.
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Protein Aliases: Channel kinase 1; Channel-kinase 1; FLJ20117; Long transient receptor potential channel 7; LTRPC ion channel family member 7; LTrpC-7; tr; Transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel, subfamily M, member 7; transient receptor potential M7; Transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-related protein, ChaK; TRMP7; TRP PLIK; TRP-PLIK
Gene Aliases: 2310022G15Rik; 4833414K03Rik; 5033407O22Rik; ALSPDC; CHAK; CHAK1; Ltpr7; LTrpC-7; LTRPC7; TRP-PLIK; TRPM7; TRPPLIK