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Invitrogen
TRPM7 Polyclonal Antibody
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FIGURE: 1 / 3
TRPM7 Antibody (PA5-15302) in IHC (P)
Immunohistochemistry analysis of TRPM7 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with TRPM7 polyclonal antibody (Product # PA5-15302) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepa... View More
Product Details
PA5-15302
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1821-1850 amino acids from the C-terminal region of human TRPM7 (CHAK1)
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Channel kinase 1; Channel-kinase 1; FLJ20117; Long transient receptor potential channel 7; LTRPC ion channel family member 7; LTrpC-7; tr; Transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel, subfamily M, member 7; transient receptor potential M7; Transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-related protein, ChaK; TRMP7; TRP PLIK; TRP-PLIK
Gene Aliases: 2310022G15Rik; 4833414K03Rik; 5033407O22Rik; ALSPDC; CHAK; CHAK1; Ltpr7; LTrpC-7; LTRPC7; TRP-PLIK; TRPM7; TRPPLIK
UniProt ID: (Human) Q96QT4, (Mouse) Q923J1
Entrez Gene ID: (Human) 54822, (Mouse) 58800
actin binding
protein serine/threonine kinase activity
calcium channel activity
ATP binding
myosin binding
metal ion binding
nucleotide binding
protein kinase activity
ion channel activity
cation channel activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ion channel
transporter
cellular magnesium ion homeostasis
calcium-dependent cell-matrix adhesion
actomyosin structure organization
protein autophosphorylation
protein tetramerization
necroptotic process
calcium ion transmembrane transport
protein phosphorylation
transport
ion transport
cation transport
calcium ion transport
memory
programmed cell death
phosphorylation
positive regulation of apoptotic process
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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