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Proteintech
TRPM8 Polyclonal Antibody
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Product Details
12813-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRPM8 Fusion Protein Ag3483 (66-234 aa encoded by BC001135)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Amount
22.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SFLPVHTIV LIRENVCKCG YAQSQHMEGT QINQSEKWNY KKHTKEFPTD AFGDIQFETL GKKGKYIRLS CDTDAEILYE LLTQHWHLKT PNLVISVTGG AKNFALKPRM RKIFSRLIYI AQSKGAWILT GGTHYGLMKY IGEVVRDNTI SRSSEENIVA IGIAAWGMVS NRDTLIRNCD AEVPVGQEEV C (66-234 aa encoded by BC001135)
Target Information
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium channel; cation channel; Long transient receptor potential channel 6; LTrpC-6; MGC2849; short form of the TRPM8 cationic channel; sTRPM8-18; 18kDa non-channel protein; sM8alpha; sTRPM8-18; 18kDa non-channel protein; sTRPM8(2p-6b/+3pp); sTRPM8-26; 26kDa non-channel protein; sTRPM8(1-6b); sTRPM8-9; 9kDa non-channel protein; sM8beta; sTRPM8-9; 9kDa non-channel protein; sTRPM8(3p-6b); Transient receptor potential cation channel subfamily M member 8; Transient receptor potential p8; transient receptor potential subfamily M member 8; transmembrane ion channel; TRP-P8; Trp-p8; TRPM8 cationic channel; TRPM8 channel; TRPM8 isoform; 118kDa channel protein; TRPM8(3p-22b); TRPM8 isoform; 119kDa channel protein; TRPM8(3p-26.2); TRPM8 isoform; 121kDa channel protein; TRPM8(1-22p); TRPM8 isoform; 121kDa channel protein; TRPM8(2p-26.1); TRPM8 isoform; 127kDa channel protein; TRPM8(1-22b); TRPM8 isoform; 26kDa channel protein; TRPM8(18a-26.2); TRPM8 isoform; 27kDa channel protein; TRPM8(17p-26.1); TRPM8 isoform; 27kDa channel protein; TRPM8(17pp-26.2); TRPM8 isoform; 35kDa channel protein; TRPM8(17p-26.1); TRPM8 isoform; 35kDa channel protein; TRPM8(17pp-26.2); TRPM8 isoform; 76kDa channel protein; TRPM8(9p-22p); TRPM8 isoform; 83kDa channel protein; TRPM8(5a-26.2); TRPM8 isoform; 83kDa channel protein; TRPM8(9p-26.2); TRPM8 isoform; putative 106kDa channel protein; TRPM8(3p-26.2/+intron3p; TRPM8 isoform; putative 122kDa channel protein; TRPM8(3p-26.2/+intron3p); TRPM8 isoform; putative 17kDa non-channel protein; TRPM8(15a-26.2/-16b; TRPM8 isoform; putative 23kDa channel protein; TRPM8(16a-26.2/+intron16; TRPM8 isoform; putative 29kDa channel protein; TRPM8(17p-22p); TRPM8 isoform; putative 33kDa channel protein; TRPM8(18a-26.2/-23; TRPM8 isoform; putative 35kDa channel protein; TRPM8(17pp-22b); TRPM8 isoform; putative 37kDa channel protein; TRPM8(17pp-26.2/-25); TRPM8 isoform; putative 50kDa channel protein; TRPM8(16a-26.2/+intron16); TRPM8 isoform; putative 51kDa protein; TRPM8(2p-26.2/+4a; TRPM8 isoform; putative 73kDa channel protein; TRPM8(3p-26.2/+16d); TRPM8 isoform; putative 83kDa channel protein; TRPM8(3p-26.1/-7); TRPM8 isoform; putative 95kDa channel protein; TRPM8(3p-22b/-4b; unnamed protein product
Gene Aliases: LTrpC-6; LTRPC6; trp-p8; TRPM8; TRPP8
UniProt ID: (Human) Q7Z2W7
Entrez Gene ID: (Human) 79054
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