Reconstitute with 100 µL of distilled water.
Centrifuge to remove any insoluble material.
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cold menthol receptor 1; cold/menthol receptor 1; Long transient receptor potential channel 6; LTrpC-6; MGC2849; Transient receptor potential cation channel subfamily M member 8; Transient receptor potential p8; transient receptor potential-p8; TRP ion channel TRPM8; Trp-p8
Gene Aliases: CMR1; LTrpC-6; LTRPC6; Trp-p8; Trpm8; TRPP8