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Invitrogen
TRPM8 Polyclonal Antibody
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Product Details
PA5-34286
Product Specifications
Species Reactivity
Bat,
Dog,
Chicken,
Horse,
Guinea pig,
Hamster,
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 15 amino acid peptide from internal region of human TRPM8.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TRPM8 is a receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH and involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. TRPM8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. TRPM8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, TRPM8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding TRPM8 were hardly detected or not detected in the corresponding normal human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium channel; cation channel; Cold menthol receptor 1; cold/menthol receptor 1; Long transient receptor potential channel 6; LTrpC-6; menthol receptor; MGC2849; short form of the TRPM8 cationic channel; sTRPM8-18; 18kDa non-channel protein; sM8alpha; sTRPM8-18; 18kDa non-channel protein; sTRPM8(2p-6b/+3pp); sTRPM8-26; 26kDa non-channel protein; sTRPM8(1-6b); sTRPM8-9; 9kDa non-channel protein; sM8beta; sTRPM8-9; 9kDa non-channel protein; sTRPM8(3p-6b); transient potential cation channel subfamily M member 8; Transient receptor potential cation channel subfamily M member 8; transient receptor potential cation channel, subfamily M, member 8; transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime; transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime; transient receptor potential M8 protein; Transient receptor potential p8; transient receptor potential subfamily M member 8; transient receptor potential-p8; transmembrane ion channel; TRP-P8; TRP ion channel TRPM8; Trp-p8; TRPM8 cationic channel; TRPM8 channel; TRPM8 isoform; 118kDa channel protein; TRPM8(3p-22b); TRPM8 isoform; 119kDa channel protein; TRPM8(3p-26.2); TRPM8 isoform; 121kDa channel protein; TRPM8(1-22p); TRPM8 isoform; 121kDa channel protein; TRPM8(2p-26.1); TRPM8 isoform; 127kDa channel protein; TRPM8(1-22b); TRPM8 isoform; 26kDa channel protein; TRPM8(18a-26.2); TRPM8 isoform; 27kDa channel protein; TRPM8(17p-26.1); TRPM8 isoform; 27kDa channel protein; TRPM8(17pp-26.2); TRPM8 isoform; 35kDa channel protein; TRPM8(17p-26.1); TRPM8 isoform; 35kDa channel protein; TRPM8(17pp-26.2); TRPM8 isoform; 76kDa channel protein; TRPM8(9p-22p); TRPM8 isoform; 83kDa channel protein; TRPM8(5a-26.2); TRPM8 isoform; 83kDa channel protein; TRPM8(9p-26.2); TRPM8 isoform; putative 106kDa channel protein; TRPM8(3p-26.2/+intron3p; TRPM8 isoform; putative 122kDa channel protein; TRPM8(3p-26.2/+intron3p); TRPM8 isoform; putative 17kDa non-channel protein; TRPM8(15a-26.2/-16b; TRPM8 isoform; putative 23kDa channel protein; TRPM8(16a-26.2/+intron16; TRPM8 isoform; putative 29kDa channel protein; TRPM8(17p-22p); TRPM8 isoform; putative 33kDa channel protein; TRPM8(18a-26.2/-23; TRPM8 isoform; putative 35kDa channel protein; TRPM8(17pp-22b); TRPM8 isoform; putative 37kDa channel protein; TRPM8(17pp-26.2/-25); TRPM8 isoform; putative 50kDa channel protein; TRPM8(16a-26.2/+intron16); TRPM8 isoform; putative 51kDa protein; TRPM8(2p-26.2/+4a; TRPM8 isoform; putative 73kDa channel protein; TRPM8(3p-26.2/+16d); TRPM8 isoform; putative 83kDa channel protein; TRPM8(3p-26.1/-7); TRPM8 isoform; putative 95kDa channel protein; TRPM8(3p-22b/-4b; unnamed protein product
Gene Aliases: CMR1; I79_024425; LTrpC-6; LTRPC6; Trp-p8; TRPM8; TRPP8
UniProt ID: (Human) Q7Z2W7, (Rat) Q8R455, (Mouse) Q8R4D5
ion transport
calcium ion transport
cellular calcium ion homeostasis
response to temperature stimulus
response to cold
calcium-mediated signaling
ion transmembrane transport
thermoception
transmembrane transport
calcium ion transmembrane transport
positive regulation of cold-induced thermogenesis
detection of temperature stimulus
protein homotetramerization
protein homotrimerization
transport
cation transport
response to stimulus
sensory perception of temperature stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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