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Invitrogen
TRPML1 Polyclonal Antibody
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Product Details
PA5-111029
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human TRPML1. Recombinant protein control fragment (Product #RP-95585).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DTIKHPGGAG AEESELQAYI AQCQDSPTSG KFRRGSGSAC SLLCCCGRDP SE
Highest antigen sequence indentity to the following orthologs: Mouse - 87%, Rat - 85%.
Target Information
Defects in Mucolipin-1 are the cause of mucolipidosis type IV (MLIV), also known as sialolipidosis. MLIV is an autosomal recessive lysosomal storage disorder characterized by severe psychomotor retardation and ophthalmologic abnormalities, including corneal opacity, retinal degeneration and strabismus. Storage bodies of lipids and water-soluble substances are seen by electron microscopy in almost every cell type of the patients. Most patients are unable to speak or walk independently and reach a maximal developmental level of 1-2 years. All patients have constitutive achlorhydia associated with a secondary elevation of serum gastrin levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MCLN1; MCOLN1 mucolipin 1; MG-2; MGC7172; ML1; Mucolipidin; mucolipidosis type IV protein; mucolipin 1; Mucolipin-1; transient receptor potential cation channel mucolipin subfamily member 1; Transient receptor potential channel mucolipin 1; transient receptor potential mucolipin 1; TRPML1; unnamed protein product
Gene Aliases: LECD; MCOLN1; MG-2; ML1; ML4; MLIV; MST080; MSTP080; TRP-ML1; TRPM-L1; TRPML1
UniProt ID: (Human) Q9GZU1
Entrez Gene ID: (Human) 57192
anion channel activity
cation channel activity
calcium channel activity
potassium channel activity
sodium channel activity
iron ion transmembrane transporter activity
protein binding
lipid binding
identical protein binding
NAADP-sensitive calcium-release channel activity
intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity
ligand-gated calcium channel activity
adaptive immune response
immune system process
ion transport
cation transport
calcium ion transport
lysosome organization
calcium-mediated signaling
transferrin transport
ion transmembrane transport
iron ion transmembrane transport
sodium ion transmembrane transport
negative regulation of innate immune response
release of sequestered calcium ion into cytosol
protein homotetramerization
calcium ion transmembrane transport
cellular response to calcium ion
cellular response to pH
potassium ion transmembrane transport
phagosome maturation
autophagosome maturation
cation transmembrane transport
anion transmembrane transport
antibacterial innate immune response
negative regulation of protein localization to nucleus
positive regulation of protein localization to nucleus
calcium ion export
positive regulation of lysosome organization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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