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Invitrogen
TRPS1 Polyclonal Antibody
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Product Details
PA5-106538
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TRPS1(Accession Q9UHF7), corresponding to amino acid residues K126-G176.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TRPS1.
Target Information
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Tricho-rhino-phalangeal syndrome type I protein; trichorhinophalangeal syndrome I; Zinc finger protein GC79; Zinc finger transcription factor Trps1
Gene Aliases: AI115454; AI447310; D15Ertd586e; GC79; LGCR; TRPS1
UniProt ID: (Human) Q9UHF7
Entrez Gene ID: (Human) 7227, (Mouse) 83925
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
DNA binding
sequence-specific DNA binding
metal ion binding
DNA-binding transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
transcription from RNA polymerase II promoter
NLS-bearing protein import into nucleus
heart development
organ morphogenesis
tissue development
regulation of chondrocyte differentiation
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
cell development
digestive tract development
anatomical structure formation involved in morphogenesis
chondrocyte differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of histone deacetylation
negative regulation of transcription, DNA-templated
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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