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Invitrogen
TRPV2 Polyclonal Antibody
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FIGURE: 1 / 1
TRPV2 Antibody (PA1-18346) in ICC/IF
Frontiers in cell and developmental biology 2023 -
FIGURE 3 Protein expression of TRPV2 and TRPV4 in hCMEC/D3. (A) Expression of TRPV2 and TRPV4 determined by Western blot of total crude proteins obtained from two different protein extractions of hCMEC/D3. beta-actin served as a loading control housekeeping protein. (B) Confocal immunofluorescence localization of TRPV2 and TRPV4 in hCMEC/D3. TRPV2 or TRPV4 (green) and nuclei (blue) were stained in hCMEC/D3 ... View More
Product Details
PA1-18346
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues C-K(744) N S A S E E D H L P L Q V L Q S P(761) of rat VRL-1.
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent.
Target Information
VLR-1 is a calcium-permeable, non-selective cation channel with an outward rectification, that seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. VRL-1 does not respond to capsaicin, acid, or moderate heat, but instead is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Osm-9-like TRP channel 2; OTRPC2; RP23-234K24.7; Stretch-activated channel 2B; Transient receptor potential cation channel subfamily V member 2; TrpV2; unnamed protein product; Vanilloid receptor-like protein 1; VRL-1
Gene Aliases: Sac2b; TRPV2; VRL; VRL-1; VRL1
UniProt ID: (Human) Q9Y5S1, (Rat) Q9WUD2
Entrez Gene ID: (Human) 51393, (Rat) 29465
ion transport
calcium ion transport
sensory perception
response to temperature stimulus
ion transmembrane transport
positive regulation of axon extension
transmembrane transport
calcium ion transmembrane transport
positive regulation of calcium ion import
calcium ion import across plasma membrane
positive regulation of cold-induced thermogenesis
apoptotic process
response to heat
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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