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Proteintech

TRPV4 Polyclonal Antibody

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TRPV4 Polyclonal Antibody

Product Details

27892-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TRPV4 fusion protein Ag27253
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Amount

67.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MADSSEGPRA GPGEVAELPG DESGTPGGEA FPLSSLANLF EGEDGSLSPS PADASRPAGP GDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK KAPMDSLFDY GTYRHHSSDN KRWRKKIIEK QPQSPKAPAP QPPPILKVFN RPILFDIVSR GSTADLDGLL PFLLTHKKRL TDEEFREPST GKTCLPKALL NLSNGRNDTI

Target Information

TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ion channel; ion channel protein; Osm-9-like TRP channel 4; OSM9-like transient receptor potential channel 4; osmosensitive transient receptor potential channel 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; Transient receptor potential protein 12; TRP12; TRPV4; Vanilloi; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; vanilloid receptor-related osmotically activated channel; Vanilloid receptor-related osmotically-activated channel; VR-OAC; VRL-2

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Gene Aliases: BCYM3; CMT2C; HMSN2C; OTRPC4; SMAL; SPSMA; SSQTL1; TRP12; TRPV4; VRL2; VROAC

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UniProt ID: (Human) Q9HBA0

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Entrez Gene ID: (Human) 59341

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Function(s)
nucleotide binding actin binding osmosensor activity protein kinase C binding ion channel activity cation channel activity calcium channel activity protein binding calmodulin binding ATP binding microtubule binding lipid binding stretch-activated, cation-selective, calcium channel activity protein kinase binding SH2 domain binding identical protein binding alpha-tubulin binding metal ion binding beta-tubulin binding actin filament binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia diet induced thermogenesis ion transport calcium ion transport cellular calcium ion homeostasis cell volume homeostasis response to osmotic stress hypotonic response actin filament organization cell-cell junction assembly positive regulation of cytosolic calcium ion concentration osmosensory signaling pathway response to mechanical stimulus positive regulation of gene expression positive regulation of macrophage chemotaxis negative regulation of neuron projection development actin cytoskeleton organization vasopressin secretion positive regulation of microtubule depolymerization positive regulation of interleukin-6 production response to insulin ion transmembrane transport cellular response to heat hyperosmotic salinity response glucose homeostasis positive regulation of vascular permeability cortical microtubule organization positive regulation of striated muscle contraction positive regulation of JNK cascade microtubule polymerization regulation of response to osmotic stress positive regulation of inflammatory response multicellular organismal water homeostasis transmembrane transport cartilage development involved in endochondral bone morphogenesis positive regulation of ERK1 and ERK2 cascade calcium ion import calcium ion transmembrane transport cellular response to osmotic stress cellular hypotonic response cellular hypotonic salinity response positive regulation of monocyte chemotactic protein-1 production positive regulation of macrophage inflammatory protein 1 alpha production positive regulation of chemokine (C-C motif) ligand 5 production energy homeostasis blood vessel endothelial cell delamination calcium ion import across plasma membrane calcium ion import into cytosol negative regulation of brown fat cell differentiation regulation of aerobic respiration positive regulation of chemokine (C-X-C motif) ligand 1 production
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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