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Alomone Labs, LTD
TRPV4 Polyclonal Antibody
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Product Details
ACC-034-GP200UL
Product Specifications
Species Reactivity
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CDGHQQGYAPKWRAEDAPL, corresponding to amino acid residues 853-871 of rat TRPV4, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel, activated in response to systemic osmotic pressure. Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. TRPV4 is a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The TRPV4 protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in the TRPV4 gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Osm-9-like TRP channel 4; osmosensitive transient receptor potential channel 4; OTRPC4; Transient receptor potential cation channel subfamily V member 4; transient receptor potential cation channel, subfamily 5, member 4; TrpV4; Vanilloi; vanilloid receptor-related osmotically activated channel (Vroac); Vanilloid receptor-related osmotically-activated channel; VR-OAC
Gene Aliases: Otrpc4; Trpv4; Vroac
UniProt ID: (Rat) Q9ERZ8
Entrez Gene ID: (Rat) 66026
calcium ion transport
cellular calcium ion homeostasis
response to osmotic stress
hypotonic response
actin filament organization
cell-cell junction assembly
positive regulation of cytosolic calcium ion concentration
osmosensory signaling pathway
negative regulation of neuron projection development
vasopressin secretion
positive regulation of microtubule depolymerization
actin cytoskeleton reorganization
cellular response to heat
hyperosmotic salinity response
cortical microtubule organization
microtubule polymerization
regulation of response to osmotic stress
calcium ion import
calcium ion transmembrane transport
cellular response to osmotic stress
cellular hypotonic response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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