|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat, Mouse|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide from aa region 300-400 of mouse TRPV4 conjugated to an immunogenic carrier protein was used as the antigen|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:300-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
Glycerol (1:1) may be added for additional stability.
Reconstitute in 100 ul of sterile water.
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats.
OSR00136W was used in western blot to investigate the role of TRPV4 in stress-induced bladder dysfunction using an a rat model
|Merrill L,Vizzard MA||American journal of physiology. Regulatory, integrative and comparative physiology (307:R471)||2014|
Increased TRPV4 expression in urinary bladder and lumbosacral dorsal root ganglia in mice with chronic overexpression of NGF in urothelium.
OSR00136W was used in western blot to study the elevated urinary bladder and lumbosacral dorsal root ganglion expression of TRPV4 in transgenic mice overexpressing NGF in the urothelium
|Girard BM,Merrill L,Malley S,Vizzard MA||Journal of molecular neuroscience : MN (51:602)||2013|