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|Tested species reactivity||Rat|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide from the 1t extracellular domain of rat TRPV5 conjugated to an immunogenic carrier protein|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:300-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Reconstitute with 100 ul of distilled water.
Centrifuge to remove any insoluble material.
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation. Exclusively expressed in kidney. Belongs to the transient receptor family, TrpV subfamily.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Calciu; Calcium transporter 2; CaT2; ECaC1; Epithelial calcium channel 1; Osm-9-like TRP channel 3; OTRPC3; Transient receptor potential cation channel subfamily V member 5; TrpV5
CaT2; Ecac; Ecac1; Trpv5