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Invitrogen

TSC1 Polyclonal Antibody

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TSC1 Polyclonal Antibody

Product Details

PA5-20130

Applications
Tested Dilution
Publications

Western Blot (WB)

2-4 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 15 amino acid peptide from the carboxy terminus of human TSC1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11153469

Product Specific Information

A suggested positive control is C2C12 cell lysate.

PA5-20130 can be used with blocking peptide PEP-0248.

Target Information

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Hamartin; HGNC:12362; KIAA0243; MGC86987; OTTHUMP00000022439; OTTHUMP00000198378; Tuberous sclerosis 1 protein; Tuberous sclerosis 1 protein homolog; unnamed protein product

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Gene Aliases: KIAA0243; LAM; TSC; TSC1

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UniProt ID: (Human) Q92574, (Mouse) Q9EP53

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Entrez Gene ID: (Human) 7248, (Mouse) 64930

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Function(s)
protein binding Hsp70 protein binding ATPase inhibitor activity protein binding involved in protein folding chaperone binding Hsp90 protein binding GTPase regulator activity GTPase activating protein binding protein N-terminus binding
Process(es)
kidney development neural tube closure regulation of cell-matrix adhesion adaptive immune response protein folding potassium ion transport cell-matrix adhesion nervous system development cell proliferation negative regulation of cell proliferation associative learning adult locomotory behavior cellular response to starvation negative regulation of macroautophagy hippocampus development cerebral cortex development cell projection organization negative regulation of TOR signaling negative regulation of ATPase activity response to insulin cellular response to decreased oxygen levels TORC1 signaling myelination memory T cell differentiation negative regulation of cell size glucose import synapse organization protein stabilization regulation of stress fiber assembly regulation of cell cycle positive regulation of focal adhesion assembly cardiac muscle cell differentiation activation of GTPase activity negative regulation of TORC1 signaling positive regulation of TORC1 signaling rRNA export from nucleus regulation of translation embryo development negative regulation of translation regulation of actin cytoskeleton organization regulation of GTPase activity regulation of phosphoprotein phosphatase activity regulation of protein kinase activity negative regulation of insulin receptor signaling pathway protein heterooligomerization regulation of focal adhesion assembly
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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