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Immunogen sequence: KLEQASGASSS QEAGSSQAAK EDETSDGQAS GEQEEAGPSS SQAGPSNGVA PLPRSALLVQ LATARPRPVK ARPLDWRVQS KDWPH
Highest antigen sequence identity to the following orthologs - mouse 75%, rat 76%.
TSEN34 encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CTD-3093M3.1; HsSen34; leukocyte receptor cluster (LRC) member 5; Leukocyte receptor cluster member 5; tRNA-intron endonuclease Sen34; tRNA-splicing endonuclease subunit Sen34; TSEN34 tRNA splicing endonuclease subunit
Gene Aliases: LENG5; PCH2C; SEN34; SEN34L; TSEN34
UniProt ID: (Human) Q9BSV6
Entrez Gene ID: (Human) 79042
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