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Product Details
PA5-53248
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human TSG. Recombinant protein control fragment (Product #RP-90897).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2648991
Product Specific Information
Immunogen sequence: DECCDCVGMC NPRNYSDTPP TSKSTVEELH EPIPSLFRAL TEGDTQLNWN IVSFPVAEEL SHHENLVSFL ETVNQPHHQN VSVPSNNVHA PYSSDKEHMC TVVYFDDCMS IHQCKISCES MGASKYRWFH NACCECIGPE CIDYGSKTVK^M
^M
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: twisted gastrulation homolog 1; Twisted gastrulation protein homolog 1
Gene Aliases: PSEC0250; TSG; TWSG1
UniProt ID: (Human) Q9GZX9
Entrez Gene ID: (Human) 57045
ossification
mesoderm formation
salivary gland morphogenesis
hemopoiesis
cell differentiation
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
forebrain development
camera-type eye development
negative regulation of osteoblast differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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