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Proteintech
TSG101 Polyclonal Antibody
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Product Details
28283-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TSG101 Fusion Protein Ag28569
Conjugate
Form
Liquid
Concentration
267 µg/mL
Amount
40.05 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
TSG101-4A10 recognizes TSG101 protein, the product of a recently identified Tumor Susceptibility Gene whose inactivation in mouse fibroblasts results in cell transformation and the ability of those cells to form tumors in nude mice. The TSG101 gene encodes a 46 kDa protein and contains a proline-rich domain and a leucine-zipper motif within a coiled-coil domain near the carboxyl terminus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ESCRT-I complex subunit TSG101; ESCRTI complex subunit TSG101; TSG 101; tumor susceptibility gene 10; tumor susceptibility gene 101; Tumor susceptibility gene 101 protein; tumor susceptibility protein
Gene Aliases: AI255943; CC2; TSG10; TSG101; VPS23
UniProt ID: (Human) Q99816, (Mouse) Q61187
Entrez Gene ID: (Human) 7251, (Mouse) 22088
DNA binding
transcription corepressor activity
protein binding
ubiquitin protein ligase binding
protein homodimerization activity
ubiquitin binding
macromolecular complex binding
virion binding
calcium-dependent protein binding
ligand-dependent nuclear receptor transcription coactivator activity
ubiquitin-protein ligase
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
extracellular transport
negative regulation of epidermal growth factor-activated receptor activity
negative regulation of cell proliferation
endosome to lysosome transport
protein transport
macroautophagy
viral release from host cell
cell differentiation
keratinocyte differentiation
multivesicular body assembly
viral budding via host ESCRT complex
negative regulation of epidermal growth factor receptor signaling pathway
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
regulation of MAP kinase activity
viral budding
cell division
regulation of cell cycle
membrane fission
autophagosome maturation
positive regulation of exosomal secretion
regulation of extracellular exosome assembly
positive regulation of viral budding via host ESCRT complex
exosomal secretion
positive regulation of ubiquitin-dependent endocytosis
cellular protein modification process
protein monoubiquitination
transport
cell cycle
cell cycle arrest
viral process
regulation of growth
negative regulation of transcription, DNA-templated
positive regulation of viral process
positive regulation of viral release from host cell
regulation of nucleic acid-templated transcription
regulation of viral budding via host ESCRT complex
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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