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Proteintech
TSHR Polyclonal Antibody
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Product Details
14450-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TSHR Fusion Protein Ag5957 (1-253 aa encoded by BC063613)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This rabbit polyclonal antibody raised against N-terminal region (1-253 aa) of human TSHR can detect subunit A with an experimentally determined molecular weight of 62-70 kDa under reducing condition.
Immunogen sequence: MRPADLLQL VLLLDLPRDL GGMGCSSPPC ECHQEEDFRV TCKDIQRIPS LPPSTQTLKL IETHLRTIPS HAFSNLPNIS RIYVSIDVTL QQLESHSFYN LSKVTHIEIR NTRNLTYIDP DALKELPLLK FLGIFNTGLK MFPDLTKVYS TDIFFILEIT DNPYMTSIPV NAFQGLCNET LTLKLYNNGF TSVQGYAFNG TKLDAVYLNK NKYLTVIDKD AFGGVYSGPS LLLPLGRKSL SFETQKAPRS SMPS (1-253 aa encoded by BC063613)
Target Information
TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC141920; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2; Thyroid-stimulating hormone receptor; Thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH-R
Gene Aliases: AI481368; CHNG1; hTSHR-I; hypothroid; hyt; LGR3; pet; TSHR; TSHRA
UniProt ID: (Human) P16473, (Mouse) P47750, (Rat) P21463
Entrez Gene ID: (Human) 7253, (Mouse) 22095, (Rat) 25360
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
cell-cell signaling
nervous system development
positive regulation of cell proliferation
hormone-mediated signaling pathway
thyroid-stimulating hormone signaling pathway
signal transduction
adult locomotory behavior
B cell differentiation
regulation of locomotion
positive regulation of multicellular organism growth
inner ear receptor cell development
inner ear receptor stereocilium organization
dopaminergic neuron differentiation
cochlea morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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