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Invitrogen
TSKU Polyclonal Antibody
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FIGURE: 1 / 1
TSKU Antibody (PA5-48041) in IHC (P)
Immunohistochemical analysis of TSKU in immersion fixed paraffin-embedded sections of human colon cancer tissue. Samples were incubated in TSKU polyclonal antibody (Product # PA5-48041) using a dilution of 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-basic. Tissue was stained using the Anti-Goa... View More
Product Details
PA5-48041
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Tsukushi/TSK Thr17-Leu353
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse TSK is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
The TSKU gene encodes Tsukushi, a member of the small leucine-rich proteoglycan (SLRP) family, playing crucial roles in cellular signaling, growth, and development. Tsukushi is characterized by its involvement in various biological processes, including immune regulation, tissue remodeling, and metabolic homeostasis. It is a hepatokine released in response to conditions like nonalcoholic fatty liver disease (NAFLD), influencing metabolic traits and contributing to conditions such as dyslipidemia and cardiovascular diseases. Tsukushi impacts energy expenditure by modulating brown fat thermogenesis, thereby affecting metabolic homeostasis and obesity-related metabolic traits. As an extracellular matrix component, Tsukushi participates in signaling pathways that regulate cell proliferation, migration, and differentiation, impacting organ development and pathophysiological processes. Its role in metabolic and inflammatory diseases presents it as a potential biomarker and therapeutic target in conditions characterized by altered metabolic and inflammatory states. Ongoing research further elucidates Tsukushi's mechanisms and interactions, contributing to our understanding of its multifunctional roles in health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E2-induced gene 4 protein; leucine rich repeat containing 54; Leucine-rich repeat-containing protein 54; Tsukushi; tsukushi homolog; tsukushi small leucine rich proteoglycan homolog
Gene Aliases: E2IG4; LRRC54; TSK; TSKU; UNQ850/PRO1788
UniProt ID: (Human) Q8WUA8
Entrez Gene ID: (Human) 25987
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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