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Invitrogen
TSLP Receptor Polyclonal Antibody
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FIGURE: 1 / 1
TSLP Receptor Antibody (PA5-87680) in WB
Western blot analysis of TSLP Receptor in extracts of various cell lines. Samples were incubated with TSLP Receptor Polyclonal antibody (Product # PA5-87680) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-87680
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 23-231 of human CRLF2 (NP_0714312)
Conjugate
Form
Liquid
Concentration
0.58 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QGGAAEGVQI QIIYFNLETV QVTWNASKYS RTNLTFHYRF NGDEAYDQCT NYLLQEGHTS GCLLDAEQRD DILYFSIRNG THPVFTASRW MVYYLKPSSP KHVRFSWHQD AVTVTCSDLS YGDLLYEVQY RSPFDTEWQS KQENTCNVTI EGLDAEKCYS FWVRVKAMED VYGPDTYPSD WSEVTCWQRG EIRDACAETP TPPKPKLSK; Positive Samples: 293T, Jurkat, Mouse liver, Rat brain; Cellular Location: Cell membrane, Single-pass type I membrane protein
Target Information
Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CRLM-2; cytokine receptor; cytokine receptor CRL2 precusor; Cytokine receptor-like 2; Cytokine receptor-like factor 2; Cytokine receptor-like molecule 2; delta 1; IL-XR; lymphocyte antigen 114; P2RY8/CRLF2 fusion; Thymic stromal lymphopoietin protein receptor; thymic stromal-derived lymphopoietin receptor; thymic stromal-derived lymphopoietin, receptor; transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; TSLP receptor; TSLPR2; Type I cytokine receptor delta 1; unnamed protein product; WI2-87105E3.1
Gene Aliases: CRL2; CRLF2; CRLF2Y; CRLM2; ILXR; Ly114; Tpte2; TSLPR
UniProt ID: (Human) Q9HC73, (Mouse) Q8CII9
Entrez Gene ID: (Human) 64109, (Mouse) 57914, (Rat) 171499
cell surface receptor signaling pathway
positive regulation of cell proliferation
cytokine-mediated signaling pathway
positive regulation of interleukin-5 production
positive regulation of mast cell activation
positive regulation of STAT cascade
immunoglobulin secretion involved in immune response
inflammatory response
T-helper 2 cell cytokine production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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