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Positive Samples: K-562, HeLa, Mouse spleen, Mouse brain, Rat thymus, Rat spleen
Immunogen sequence: GFQDIPKRCL KAREHFGTVK THLTSLKTKF PAEQYYRFHE HWRFVLQRLV FLAAFVVYLE TETLVTREAV TEILGIEPDR EKGFHLDVED YLSGVLILAS E
Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.
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Protein Aliases: C3PO; Component 3 of promoter of RISC; recombination hotspot associated factor; recombination hotspot-binding protein; TB-RBP; testis brain-RNA binding protein; Testis/brain RNA-binding protein; testis/brain-RNA-binding protein; Translin
Gene Aliases: 2610034C24Rik; AU040286; BCLF-1; C3PO; RCHF1; REHF-1; TB-RBP; TBRBP; TRSLN; TSN
UniProt ID: (Human) Q15631, (Mouse) Q62348
Entrez Gene ID: (Human) 7247, (Rat) 60381, (Mouse) 22099
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