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Invitrogen
TSPO Polyclonal Antibody
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FIGURE: 1 / 4
TSPO Antibody (PA5-103031) in IHC (P)
Immunohistochemistry analysis of TSPO in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with TSPO polyclonal antibody (Product # PA5-103031) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103031
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TSPO(Accession P30536), corresponding to amino acid residues A134-E169.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TSPO.
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; BZRP; isoquinoline-binding protein; Mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; peripheral benzodiazepine receptor; Peripheral-type benzodiazepine receptor; PKBS; Translocator protein
Gene Aliases: BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS; pk18; PKBS; PTBR; TSPO; TSPO1
UniProt ID: (Human) P30536, (Mouse) P50637
Entrez Gene ID: (Human) 706, (Mouse) 12257
protein targeting to mitochondrion
steroid biosynthetic process
C21-steroid hormone biosynthetic process
heme biosynthetic process
ion transport
anion transport
chloride transport
lipid transport
steroid metabolic process
glial cell migration
response to xenobiotic stimulus
response to manganese ion
response to vitamin B1
peripheral nervous system axon regeneration
sterol transport
adrenal gland development
negative regulation of protein ubiquitination
regulation of cholesterol transport
response to progesterone
negative regulation of tumor necrosis factor production
response to testosterone
regulation of cell proliferation
cholesterol homeostasis
positive regulation of apoptotic process
negative regulation of nitric oxide biosynthetic process
response to pain
behavioral response to pain
response to axon injury
regulation of steroid biosynthetic process
positive regulation of mitochondrial depolarization
positive regulation of calcium ion transport
contact inhibition
positive regulation of glial cell proliferation
negative regulation of glial cell proliferation
positive regulation of programmed necrotic cell death
cellular response to lipopolysaccharide
cellular response to zinc ion
cellular hypotonic response
establishment of protein localization to mitochondrion
maintenance of protein location in mitochondrion
negative regulation of macromitophagy
negative regulation of ATP metabolic process
response to acetylcholine
positive regulation of reactive oxygen species metabolic process
negative regulation of corticosterone secretion
transport
signal transduction
chemical synaptic transmission
positive regulation of necrotic cell death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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