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Bioss
TTC21B Polyclonal Antibody
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Product Details
BS-12069R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TTC21B, amino acids 1221-1316.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TTC21B (tetratricopeptide repeat domain 21B), also known as THM1, is a 1,316 amino acid protein that contains 19 TPR repeats and belongs to the TTC21 family. Localizing to cytoplasm and cytoskeleton, TTC21B exists as two alternatively spliced isoforms and is thought to negatively regulate Shh signal transduction. TTC21B may also be involved in retrograde intraflagellar transport in cilia, and is encoded by a gene that maps to human chromosome 2q24.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Intraflagellar transport 139 homolog; line 158; putative protein product of Nbla10696; Tetratricopeptide repeat protein 21B; Tetratricopeptide repeat-containing hedgehog modulator 1; TPR repeat protein 21B
Gene Aliases: 2410066K11Rik; aln; ATD4; IFT139; IFT139B; JBTS11; KIAA1992; mKIAA1992; Nbla10696; NPHP12; RGD1565122; SRTD4; THM1; TTC21B
UniProt ID: (Human) Q7Z4L5, (Mouse) Q0HA38
Entrez Gene ID: (Human) 79809, (Rat) 295654, (Mouse) 73668
regulation of transcription from RNA polymerase II promoter
smoothened signaling pathway
regulation of smoothened signaling pathway
ventricular system development
forebrain dorsal/ventral pattern formation
intraciliary retrograde transport
intraciliary transport involved in cilium morphogenesis
cilium morphogenesis
protein localization to cilium
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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