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Invitrogen
TTK Polyclonal Antibody
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Product Details
PA5-149122
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human TTK, Ser281-Leu481
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
TTK is a serine/threonine kinase closely related to SPK1, PIM 1 and CDC2 serine/threonine kinases. TTK is a dual-specificity kinase, which can also phosphorylate tyrosine. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. TTK encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cancer/testis antigen 96; Dual specificity protein kinase TTK; monopolar spindle 1 kinase; monopolar spindle 1-like 1; OTTHUMP00000016778; OTTHUMP00000220743; phosphotyrosine picked threonine kinase; Phosphotyrosine picked threonine-protein kinase; PYT; threonine and tyrosine kinase; unnamed protein product
Gene Aliases: CT96; ESK; MPH1; MPS1; MPS1L1; PYT; TTK
UniProt ID: (Human) P33981
Entrez Gene ID: (Human) 7272
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
identical protein binding
kinetochore binding
protein serine kinase activity
nuclear division
spindle organization
mitotic spindle organization
chromosome segregation
mitotic spindle assembly checkpoint
positive regulation of cell proliferation
female meiosis chromosome segregation
meiotic spindle assembly checkpoint
protein localization to kinetochore
protein localization to chromosome
positive regulation of SMAD protein import into nucleus
nuclear chromosome segregation
repair of mitotic kinetochore microtubule attachment defect
protein localization to meiotic spindle midzone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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