Immunogen sequence: NSETSDGVSQ LSSALLHANH TLSTIDHLVL ETVERLGEAV RTELTTLEEV LEPRTEQVAE NV
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 85%.
TTYH1 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH1 is a Ca2+-independent, volume-sensitive large conductance chloride (Cl-) channel. TTYH1 is primarily expressed in neural tissue and upregulated in astrocytoma, glioma, and several other cancers. Recent experiments have shown that TTYH1 is an integral endoplasmic reticulum (ER) membrane protein involved in cell proliferation and is thought to play an essential role in embryonic cell growth, possibly through the Ca2+ storage/release process in ER membranes during early development.
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Protein Aliases: hTTY1; Protein tweety homolog 1; TTYH1; Tweety homolog 1
Gene Aliases: TTYH1
UniProt ID: (Human) Q9H313
Entrez Gene ID: (Human) 57348